Synthesis and assessment of the cytotoxic effect of some of 1,4-dihydropyridine derivatives which contain azole moiety

A number of 1,4-dihydropyridine derivatives (9a?d, 10a?d and 11a?d) were designed synthesized by the reaction 1,3,4-oxadiazole-5-thiones 1,2,4-triazole-5-thiones to 2,6-dibromomethyl-3,5-diethoxycarbonyl-4-(3- -nitrophenyl)-1,4-dihydropyridine. The compounds characterized using FT-IR, 1H-NMR, 13C-NMR spectral data, ESI-MS elemental analysis. cytotoxicity was evaluated in human breast cancer (MCF-7) cells based on results MTT assay. indicated that compound diethyl 4-(3-nitrophenyl)-2,6-bis[((5-(3-nitrophenyl)- 1,3,4-oxadiazol-2-yl)thio)methyl]-1,4-dihydro pyridine-3,5-dicarboxylate (9b) with (IC50 = 23?2.32 ?M) most potent derivative against MCF-7 cells. Based results, use oxadiazole moiety C2 C6 positions ring system enhanced cytotoxic potential these derivatives. Therefore, some oxadiazole-substituted 1,4-DHPs may facilitate further modifications which result discovery agents.